Staff Accountant/Payroll


We are looking for a reliable, precise and experienced professional to join our Team. This role is responsible for supporting payroll processing and a wide range of accounting duties, including fixed assets, bank and account reconciliations, and other duties as needed.



  • Prepare accounting related journal entries
  • Regularly maintain reconciliations for balance sheet accounts
  • Perform monthly bank reconciliations
  • Prepare bank deposits
  • Support the SOX testing and implementation for the Company
  • Prepare and document updates for the semi-monthly payroll submissions
  • Prepare and document the monthly benefit file submissions
  • Prepare documentation for external auditors
  • Assist in ad hoc reporting and projects as necessary


Qualifications and Experience

  • Bachelor’s Degree in Accounting, Finance or related discipline
  • 1+ years’ experience preferably in a biotech
  • Ability to use Microsoft software such as Excel and Word
  • Experience with NetSuite, Coupa, Concur, Namely payroll and Equity Edge Online are a plus
  • Excellent attention to detail
  • Strong organizational skills and ability to multi-task
  • Effective written and verbal corporate communications skills
  • A team player, willing to learn and grow with the Company


Spero has a vibrant and engaging culture of innovation and team work and we are continuing to build a top-tier team to rapidly advance our programs in a fast-paced, exciting and fun work environment. We offer a robust benefits package including premium health/dental plans, 401(k) retirement plan, incentive stock options, 4 weeks paid time off, professional development, and frequent social opportunities.

Please forward your CV/resume to

Spero Therapeutics, Inc. 675 Massachusetts Avenue, 14th Floor, Cambridge, MA 02139