Publications and Presentations Featuring Spero Therapeutics Drug Candidates and Research

Browse through key publications and presentations that have discussed our drug candidates and our work involving the treatment of bacterial infections.

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Single and multiple-ascending dose (SAD/MAD) study demonstrates the human pharmacokinetics (PK) and tolerability of SPR994 (tebipenem pivoxil hydrobromide), an oral carbapenem (CP), at the predicted therapeutic dose

September 06, 2019

Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide After Single and Multiple Ascending Oral Doses in Healthy Adult Subjects

August 23, 2019

Antimicrobial Agents and Chemotherapy, DOI: 10.1128/AAC.00618-19 Paul B. Eckburg, Akash Jain, Susannah Walpole, Grayson Moore, Luke Utley, Erika Manyak, Aaron Dane, David Melnick

Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, An Intravenous Potentiator, After Single and Multiple Ascending Doses and When Combined with Beta-Lactam Antibiotics in Healthy Subjects

August 23, 2019

Antimicrobial Agents and Chemotherapy, DOI: 10.1128/AAC.00892-19 Paul B. Eckburg, Troy Lister, Susannah Walpole, Tim Keutzer, Luke Utley, John Tomayko, Ellen Kopp, Nicholas Farinola, Scott Coleman

Activity of Investigational Polymyxin-B-Like Compound (SPR206) against Set of Enterobacteriaceae Organisms Responsible for Human Infections

June 24, 2019

Mechanism of Action of SPR206, a Next-Generation Polymyxin Active against Gram-Negative Pathogens

June 24, 2019

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Publications and Presentations Featuring Spero Therapeutics Drug Candidates and Research

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