Combating Antibiotic Resistance Is a Constant Battle
Historically, antibiotics have saved millions of lives and eased the suffering of patients. They have been dubbed “wonder drugs” and deserve much of the credit for the dramatic increase in life expectancy in the U.S. and around the world; however, they are not always effective. Over time, bacteria can develop resistance to existing drugs, making infections difficult, if not impossible, to treat.
The Institute of Medicine and federal officials have identified antibiotic resistance as an increasing threat to U.S. public health. And world health leaders have stated that antibiotic-resistant microorganisms are “nightmare bacteria” that “pose a catastrophic threat” to people in every country in the world.
Among all of the bacterial resistance challenges, Gram-negative pathogens are particularly worrisome, because they are becoming resistant to nearly all-available antibiotics. The most serious Gram-negative infections are healthcare-associated, namely Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. These infections are becoming an increasingly common challenge to treat in many hospitals due to growing resistance.
A key challenge in treating these infections is that the number of new antibiotics developed and approved has steadily decreased in the past three decades, leaving fewer options to treat resistant bacteria. Only two new classes of antibiotics have been developed in the past 15 years, and it’s been more than 30 years since a new class of antibiotic to treat Gram-negative infections has emerged.(3)
Experiencing Increase in MDR Pathogens in the Community Settings
While a majority of life-threatening infections resulting from antibiotic-resistant bacteria are historically acquired in the hospital setting, there is an increasing incidence of multi-drug resistant (MDR) pathogens in the community setting.
Currently, there are no oral antibiotics commercially available that can be used reliably in adults with MDR Gram-negative bacterial infections. This limits the ability for physicians to treat these infections without hospitalizing their patients. In addition, not having an oral option at discharge often delays the transition of care from hospital to home.
The limitations of existing therapies and traditional drug development approaches highlights the critical need for novel therapies, and in particular orally administrable agents, that are capable of overcoming these obstacles to effective patient treatment.