Biopharmaceutical Jobs That Offer
Hope to a World in Need

Experience a level of biopharma career satisfaction that comes from working
on critical global health issues backed by the support of a strong
leadership team that genuinely cares about your professional
development and success.

A Clinical Development Company Built on a Solid Foundation of Trust

The Italian word “spero” means “hope.” Spero’s mission as the leader in the field of antibiotic drug development is to give hope to patients afflicted with drug resistant infections by developing transformative anti-infective medicines. The need for more agents is greater than ever before to treat patients for whom there are no generic options. Consider too that the rate of mortality for resistant organisms is the equivalent of one Boeing 747 “Jumbo Jet” crashing each week.

At Spero Therapeutics, it’s our determined hope to become the leader at the forefront of novel treatments for multi-drug resistant bacterial infections. And we hope you’ll consider joining us on an exciting and rewarding journey of discovery and career fulfillment.

By joining our committed and highly motivated team, you’ll experience a workplace culture that is friendly, fair, challenging, supportive, and respectful. Spero Therapeutics also fosters an innovative environment that recognizes everyone’s contribution to the success of our organization. And our approachable, transparent leadership team encourages open lines of communication which leads to confidence and a high degree of camaraderie built on a solid foundation of trust.

Spero Therapeutics offers a competitive benefits package that includes:

  • Medical, Dental and Vision Insurance Coverage
  • Life and AD&D Coverage
  • Short- and Long-Term Disability Insurance Coverage
  • 401(k) Plan

Current Opportunities

  • – Cambridge, MADIRECT HIRE

    Senior/Principal Process Development Scientist

      The incumbent will be responsible for the development and execution of robust, well-understood process and timely manufacture of cGMP materials.  This will involve the rapid design of syntheses and isolations, in conjunction with the identification of key process parameters, the origin of impurities and the appropriate process controls. The ideal candidate will support API registration […]

  • – Cambridge, MADIRECT HIRE

    Senior/Clinical Project Manager

      Join an enthusiastic Clinical Development team in a growing drug discovery company.  Spero Therapeutics seeks a motivated and team-oriented individual who will be a key contributor to the overall success of Spero’s clinical development program. The Clinical Project Manager will be responsible for a broad scope of varying activities to support department and corporate […]

  • – Cambridge, MADIRECT HIRE

    Staff Accountant/Payroll

      We are looking for a reliable, precise and experienced professional to join our Team. This role is responsible for supporting payroll processing and a wide range of accounting duties, including fixed assets, bank and account reconciliations, and other duties as needed.   Responsibilities Prepare accounting related journal entries Regularly maintain reconciliations for balance sheet […]

  • – Cambridge, MADIRECT HIRE

    Accounts Payable

      We are looking for a reliable, precise and experienced professional to help us properly maintain our payable information. The Accounts Payable Specialist will maintain current accounts with vendors, and process payments by check, ACH and wires. The candidate will analyze and audit expense reports to ensure that expenses are coded to the proper projects, […]

  • – Cambridge, MADIRECT HIRE

    Associate Director/Director, Regulatory Affairs

    The Associate Director/Director, Regulatory Affairs, will lead development and implementation of registration strategies as well as develop and oversee submissions and communications with Health Authorities for assigned development programs.  Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient. Excellent interpersonal skills, ability to develop important relationships with key stakeholders, […]

Work with Us

Named one of Boston’s “Best Places to Work in 2017” by the Boston Business Journal, Spero Therapeutics is also the recipient of the first-ever 2017 Xconomy Startup of the Year Award. As proud as were are of these achievements, we’re even more grateful for the talented and extraordinary people with experience in infectious disease who have chosen to join us in our pursuits. We encourage you to take the time to learn more about us.

If you have any questions about your interest in establishing a career at Spero Therapeutics, or you would like to send us your resume, you can reach us at or simply click the “Apply” button below. We look forward to learning more about you and your career interests in Spero Therapeutics!

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