Biopharmaceutical Jobs That Offer
Hope to a World in Need

Experience a level of biopharma career satisfaction that comes from working
on critical global health issues backed by the support of a strong
leadership team that genuinely cares about your professional
development and success.

A Clinical Development Company Built on a Solid Foundation of Trust

The Italian word “spero” means “hope.” Spero’s mission as the leader in the field of antibiotic drug development is to give hope to patients afflicted with drug resistant infections by developing transformative anti-infective medicines. The need for more agents is greater than ever before to treat patients for whom there are no generic options. Consider too that the rate of mortality for resistant organisms is the equivalent of one Boeing 747 “Jumbo Jet” crashing each week.

At Spero Therapeutics, it’s our determined hope to become the leader at the forefront of novel treatments for multi-drug resistant bacterial infections. And we hope you’ll consider joining us on an exciting and rewarding journey of discovery and career fulfillment.

By joining our committed and highly motivated team, you’ll experience a workplace culture that is friendly, fair, challenging, supportive, and respectful. Spero Therapeutics also fosters an innovative environment that recognizes everyone’s contribution to the success of our organization. And our approachable, transparent leadership team encourages open lines of communication which leads to confidence and a high degree of camaraderie built on a solid foundation of trust.

Spero Therapeutics offers a competitive benefits package that includes:

  • Medical, Dental and Vision Insurance Coverage
  • Life and AD&D Coverage
  • Short- and Long-Term Disability Insurance Coverage
  • 401(k) Plan

Current Opportunities

  • October 20, 2017 – Cambridge, MADIRECT HIRE

    Clinical Microbiologist

    As a member of the Clinical Operations team, the Clinical Microbiologist will be responsible for providing clinical microbiology expertise during clinical trial development and end of study data analysis, developing a global antimicrobial susceptibility testing strategy for multiple drug products, contributing to global regulatory filings and reporting on surveillance programs. Responsibilities Manage clinical microbiology data […]

  • October 19, 2017 – Cambridge, MADIRECT HIRE

    Lab Operations Associate

    Responsibilities This role is an exciting opportunity to join Spero Therapeutics, a fast paced, growing, privately held biotech company focused on developing non-traditional therapeutics to treat serious bacterial infections. The successful candidate will play a key role in the day-to-day research operations of the Spero Therapeutics Watertown MA laboratory. This person will provide lab operations […]

  • October 17, 2017 – Cambridge, MADIRECT HIRE

    Senior Accountant, Grants & Contracts

    The Senior Accountant, Grants & Contracts will be responsible for the financial management of all Spero-held contracts, grants, cooperative agreements, or other Government or not-for-profit funding sources, including tracking costs and preparing and submitting invoices. Responsibilities Work very closely with the PI, functional leads, and Technical Program Manager at Spero to monitor the actual and […]

  • October 16, 2017 – Cambridge, MADIRECT HIRE

    Associate Director/Director, Drug Product Development & Manufacturing

    We are seeking a highly motivated individual to join our team and be an integral part of the development and manufacturing team. The position will focus on drug product development from lead optimization during drug discovery to clinical development, manufacture of clinical supplies, and development of efficient and scalable manufacturing processes. The successful candidate will […]

  • October 15, 2017 – Cambridge, MADIRECT HIRE

    Head of Quality Assurance

    This position will be responsible for developing and managing Spero’s Quality Systems to support the development of our programs and products. This individual will represent QA on project teams and ensure regulatory compliance across our development programs. Responsibilities Lead the QA program, policies, and procedures to ensure compliance with internal and external standard operating procedures […]

Work with Us

Named one of Boston’s “Best Places to Work in 2017” by the Boston Business Journal, Spero Therapeutics is also the recipient of the first-ever 2017 Xconomy Startup of the Year Award. As proud as were are of these achievements, we’re even more grateful for the talented and extraordinary people with experience in infectious disease who have chosen to join us in our pursuits. We encourage you to take the time to learn more about us.

If you have any questions about your interest in establishing a career at Spero Therapeutics, or you would like to send us your resume, you can reach us at or simply click the “Apply” button below. We look forward to learning more about you and your career interests in Spero Therapeutics!

Apply >