Biopharmaceutical Jobs That Offer
Hope to a World in Need

Experience a level of biopharma career satisfaction that comes from working
on critical global health issues backed by the support of a strong
leadership team that genuinely cares about your professional
development and success.

A Clinical Development Company Built on a Solid Foundation of Trust

The Italian word “spero” means “hope.” Spero’s mission as the leader in the field of antibiotic drug development is to give hope to patients afflicted with drug resistant infections by developing transformative anti-infective medicines. The need for more agents is greater than ever before to treat patients for whom there are no generic options. Consider too that the rate of mortality for resistant organisms is the equivalent of one Boeing 747 “Jumbo Jet” crashing each week.

At Spero Therapeutics, it’s our determined hope to become the leader at the forefront of novel treatments for multi-drug resistant bacterial infections. And we hope you’ll consider joining us on an exciting and rewarding journey of discovery and career fulfillment.

By joining our committed and highly motivated team, you’ll experience a workplace culture that is friendly, fair, challenging, supportive, and respectful. Spero Therapeutics also fosters an innovative environment that recognizes everyone’s contribution to the success of our organization. And our approachable, transparent leadership team encourages open lines of communication which leads to confidence and a high degree of camaraderie built on a solid foundation of trust.

Spero Therapeutics offers a competitive benefits package that includes:

  • Medical, Dental and Vision Insurance Coverage
  • Life and AD&D Coverage
  • Short- and Long-Term Disability Insurance Coverage
  • 401(k) Plan

Current Opportunities

  • – Cambridge, MADIRECT HIRE

    Contracts Manager (Part-Time, Temporary)

    This is a flexible-hours position and may be home-based (with visits to the Cambridge office as needed). This position is responsible for managing the contracts process for a variety of agreements including confidentiality agreements, consulting agreements, clinical study agreements, services agreements, material transfer agreements, manufacturing agreements, license agreements, and collaboration agreements.   Responsibilities Serve as the […]

  • – Cambridge, MADIRECT HIRE

    Head of Nonclinical Development

    This position will be responsible for developing, overseeing and directing the overall safety pharmacology/toxicology strategy for all pipeline programs at Spero Therapeutics. Responsibilities Apply knowledge of applicable regulatory guidelines (for example ICH, FDA, GLP) to the development of testing strategies and design of appropriate toxicology studies to ensure that all safety pharmacology/toxicology studies and assay […]

  • – Cambridge, MADIRECT HIRE

    Sr. Manager/ Director, Human Resources

    This is a great opportunity to lead Human Resources for a fast-growing biotech company. The Sr. Manager/ Director, Human Resources will serve in a dual role as HR Business Partner to some of the business groups as well as being the Employee Relations Business Partner for the entire company. This position will be based at […]

  • 20171017 – Cambridge, MADIRECT HIRE

    Senior Accountant, Grants & Contracts

    The Senior Accountant, Grants & Contracts will be responsible for the financial management of all Spero-held contracts, grants, cooperative agreements, or other Government or not-for-profit funding sources, including tracking costs and preparing and submitting invoices. Responsibilities Work very closely with the PI, functional leads, and Technical Program Manager at Spero to monitor the actual and […]

Work with Us

Named one of Boston’s “Best Places to Work in 2017” by the Boston Business Journal, Spero Therapeutics is also the recipient of the first-ever 2017 Xconomy Startup of the Year Award. As proud as were are of these achievements, we’re even more grateful for the talented and extraordinary people with experience in infectious disease who have chosen to join us in our pursuits. We encourage you to take the time to learn more about us.

If you have any questions about your interest in establishing a career at Spero Therapeutics, or you would like to send us your resume, you can reach us at or simply click the “Apply” button below. We look forward to learning more about you and your career interests in Spero Therapeutics!

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