Programs Designed to Address Unmet Needs in Bacterial Infections and Rare Diseases

Spero Therapeutics’ antibiotic pipeline is focused on areas for which the unmet medical need is greatest, the biological rationale for treatment is clear, and for which there are few approved therapies, or where the standard of care is suboptimal.

Our pipeline of anti-infective agents is one of the most unique in the industry and consists of four product candidates, including:

• Tebipenem HBr, an oral carbapenem currently being evaluated in a pivotal Phase 3 clinical trial for the treatment of complicated urinary tract infections. Tebipenem HBr is a novel investigational oral formulation of tebipenem, a carbapenem-class antibiotic marketed in Japan since 2009 for certain pediatric infections.  
• SPR720, an oral antimicrobial agent being developed for the treatment of non-tuberculous mycobacterial (NTM) lung disease.
• SPR206, a direct acting intravenous (IV)-administered next-generation polymyxin analogue in clinical development as innovative options to treat MDR Gram-negative bacterial infections within the hospital.  SPR206 has demonstrated broad Gram-negative antibacterial activity as monotherapy.

The following table illustrates our product candidates, their status, and anticipated milestones for ongoing development.

Product Candidate Pipeline and Anticipated Milestones

Information as of August 6, 2020

This chart contains forward-looking statements. Our planned development activities and anticipated milestones are based on our current assumptions, estimates and plans, which may change.